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. 2024 Jul 24;11:1429180. doi: 10.3389/fmolb.2024.1429180

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Copyright © 2024 Dutta and Acharya.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cryo-EM studies of SARS-CoV-2 spikes and its interaction with antibodies. (A) Schematic representation of SARS-CoV2 spike with its different parts color labeled with S1 (antique white), S2 (yellow), N-terminal domain (NTD, dark sea green), receptor binding domain (RBD, sea green), SD1 (misty rose), fusion peptide (FP, orange) and stem helix region (pink violet).The same color scheme was maintained throughout Figure 5 except 5G. Antibody heavy chain is shown in purple and light chain is in thistle color. (B) ACE-2 bound (human) SARS-CoV-2 XBB.1.5 spike (EMD-43324). (C) Binding patterns of different NAbs (class 1, EMD-13869), (class 2, EMD-23156), (class 3, EMD-22732), (class 4, EMD-24504) to RBD. (D) Binding of NTD-targeted Ab DH1050.1 (EMD-23277). (E) Binding of SD1-targeted Ab S3H3 (EMD-32564). (F) Binding of glycan-targeted Ab 2G12 (EMD-23094). (G) Binding of stem-helix specific Ab S2P6 along with RBM-bound S2M11 (EMD-24533).