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. 2024 Jun 27;27(8):1468–1474. doi: 10.1038/s41593-024-01682-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — a, Representative image showing CD8⁺ T-cells (green) in the cortex and corpus callosum of 5xFAD mice aged 10 months. Plaques are stained with Thiazine Red (ThR, red). Scale bar, 10 µm. Quantifications indicate the number of CD8⁺ T cells. Statistical significance was determined for n = 3 animals using unpaired two-sided Student’s t-test (GM, WT 10 m, 5xFAD 10 m, *p = 0.017; WM, WT 4 m, 5XFAD 4 m, *p = 0.011; WM, WT 10 m, 5xFAD 10 m, ***p = 0.0006). b, Representative image showing STAT1⁺ (grey) CC1⁺ oligodendrocytes (green) in the cortex (upper panel) and corpus callosum (lower panel) of WT and 5xFAD mice aged 4 and10 months. Plaques are stained with Thiazine Red (ThR, red). Scale bar, 10 µm. Quantifications indicate the percentage of CC1⁺ oligodendrocytes also positive for STAT1. Statistical significance was determined for n = 3-4 animals using unpaired two-sided Student’s t-test (GM, WT 10 m, 5xFAD 10 m, *p = 0.037; WM, WT 10 m, 5xFAD 10 m, *p = 0.040). c, Representative image showing Serpina3n⁺ (grey) CC1⁺ oligodendrocytes (green) in the cortex (upper panel) and corpus callosum (lower panel) of WT and 5xFAD mice aged 4 and10 months. Plaques are stained with Thiazine Red (ThR, red). Scale bar 10 µm. Quantifications indicate the percentage of CC1⁺ oligodendrocytes also positive for Serpina3n. Statistical significance was determined for n = 3-4 animals using unpaired two-sided Student’s t-test (GM, WT 10 m, 5xFAD 10 m, *p = 0.029; WM, WT 4 m, 5XFAD 4 m, *p = 0.028; WM, WT 10 m, 5xFAD 10 m, *p = 0.001). Each point on the graph represents one animal. Data is presented as mean ± SEM.

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