Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jun 27;27(8):1468–1474. doi: 10.1038/s41593-024-01682-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 2 — a-d, Representative image and quantification showing percentage of EdU⁺ (grey) OLIG2⁺ (green) cells in the cortex and corpus callosum of WT and 5xFAD mice aged 4 and 10 months. Plaques are stained with Thiazine Red (ThR, red). Scale bar, 10 µm. Statistical significance was determined for n = 3-4 animals using unpaired two-sided Student’s t-test (GM, WT 10 m, 5xFAD 10 m, **p = 0.0079; WM, WT 10 m, 5xFAD 10 m, *p = 0.049). e, Representative image and quantification showing number of CC1⁺ (green) oligodendrocytes in the cortex and corpus callosum of WT and 5xFAD mice aged 4 and 10 months. Plaques are stained with Thiazine Red (ThR, red). Scale bar 10 µm. Statistical significance was determined for n = 3-4 animals using unpaired two-sided Student’s t-test (GM, WT 10 m, 5xFAD 10 m, *p = 0.020; WM, WT 10 m, 5xFAD 10 m, n = 3 animals, *p = 0.029). f, Representative image and quantification showing number of BCAS1⁺ (green) oligodendrocytes in the cortex and corpus callosum of WT and 5xFAD mice aged 4 and 10 months. Plaques are stained with Thiazine Red (ThR, red). Scale bar, 10 µm. Statistical significance was determined for n = 3-4 animals using unpaired two-sided Student’s t-test (GM, WT 10 m, 5xFAD 10 m, *p = 0.020; WM, WT 4 m, 5xFAD 4 m, *p = 0.024; WM WT 10 m, 5xFAD 10 m, *p = 0.039). g, Representative image and quantification showing number of PDGFRα⁺ (green) oligodendrocyte precursor cells in the cortex and corpus callosum (lower panel) of WT and 5xFAD mice aged 4 and 10 months. Plaques are stained with Thiazine Red (ThR, red). Scale bar 10 µm. Statistical significance was determined for n = 3-4 animals using unpaired two-sided Student’s t-test (GM, WT 10 m, 5xFAD 10 m, *p = 0.026; WM, WT 10 m, 5xFAD 10 m, **p = 0.009). Each point on the graph represents one animal. Data is presented as mean ± SEM.

Source data