Table 3.

Cox proportional hazard analysis of biomarkers for PFS

Feature	Univariate analysis		Multivariate analysis
	HR (95% CI)	p value	HR (95% CI)	p value
Subtype
HRpos	Reference		Reference
TNBC	1.26 (0.72–2.20)	0.427	1.72 (0.88–3.36)	0.114
TMB group
Low	Reference		Reference
High	0.52 (0.26–1.03)	0.061	0.45 (0.21–0.94)	0.033
Somatic HRD-related gene status
Wild type	Reference		Reference
Mutated	2.52 (1.15–5.53)	0.022	2.62 (1.08–6.40)	0.034
Signature 25
Low	Reference		Reference
High	2.64 (1.13–6.19)	0.025	2.01 (0.83–4.90)	0.124
E2F target enrichment score
Low	Reference		Reference
High	1.87 (1.05–3.31)	0.033	1.43 (0.74–2.74)	0.284
AP gene set enrichment score
Low	Reference		Reference
High	0.46 (0.26–0.83)	0.009	0.46 (0.23–0.93)	0.031

CI confidence interval, HR hazard ratio