Table 2.
Associations of specific cell subpopulations with brain tissues for bipolar disorder.
| Cell Type | Panel | Tissue | N_cell | asso_p | asso_z | heter_p | heter_z |
|---|---|---|---|---|---|---|---|
| Astrocyte_1 | ATAC | Cortical plate | 120 | 0.215 | 0.773 | 0.007* | 2.030 |
| ATAC | Dorsolateral prefrontal cortex | 3 | 0.529 | −0.153 | 0.326 | 0.003 | |
| GWAS | Cortical plate | 120 | 0.179 | 0.969 | 0.507 | 0.080 | |
| GWAS | Dorsolateral prefrontal cortex | 3 | 0.339 | 0.377 | 0.658 | −0.833 | |
| RNA | Cortical plate | 120 | 0.998 | −2.708 | 0.362 | 0.434 | |
| RNA | Dorsolateral prefrontal cortex | 3 | 0.462 | −0.031 | 0.379 | 0.484 | |
| TWAS | Cortical plate | 120 | 0.038* | 1.809 | 0.967 | −1.862 | |
| TWAS | Dorsolateral prefrontal cortex | 3 | 0.231 | 0.725 | 0.001* | 1.424 | |
| Height | Cortical plate | 120 | 0.975 | −1.795 | 0.991 | −2.374 | |
| Height | Dorsolateral prefrontal cortex | 3 | 0.195 | 0.878 | 0.001 | 1.371 | |
| Astrocyte_2 | ATAC | Dorsal pallium | 91 | 0.990 | −2.266 | 0.007* | 2.393 |
| GWAS | Dorsal pallium | 91 | 0.615 | −0.314 | 0.742 | −0.620 | |
| RNA | Dorsal pallium | 91 | 1.000 | −3.613 | 0.128 | 1.152 | |
| TWAS | Dorsal pallium | 91 | 0.623 | −0.347 | 0.916 | −1.384 | |
| Height | Dorsal pallium | 91 | 0.016* | 2.342 | 0.166 | 0.942 | |
| Astrocyte_3 | ATAC | Dorsolateral prefrontal cortex | 10 | 0.040* | 1.801 | 0.767 | −0.768 |
| GWAS | Dorsolateral prefrontal cortex | 10 | 0.511 | −0.085 | 0.034* | 1.912 | |
| RNA | Dorsolateral prefrontal cortex | 10 | 0.134 | 1.087 | 0.776 | −0.744 | |
| TWAS | Dorsolateral prefrontal cortex | 10 | 0.679 | −0.476 | 0.442 | 0.141 | |
| Height | Dorsolateral prefrontal cortex | 10 | 0.532 | −0.122 | 0.636 | −0.354 | |
| Microglial cell_1 | ATAC | Cortical plate | 138 | 0.463 | 0.085 | 0.234 | 0.736 |
| GWAS | Cortical plate | 138 | 0.412 | 0.177 | 0.067 | 1.430 | |
| RNA | Cortical plate | 138 | 0.644 | −0.394 | 0.158 | 0.935 | |
| TWAS | Cortical plate | 138 | 0.071 | 1.465 | 0.237 | 0.701 | |
| Height | Cortical plate | 138 | 0.909 | −1.344 | 0.553 | −0.094 | |
| Microglial cell_2 | ATAC | Cortical plate | 5 | 0.355 | 0.327 | 0.257 | 0.515 |
| ATAC | Dorsal pallium | 1 | 0.433 | 0.114 | / | / | |
| ATAC | Dorsolateral prefrontal cortex | 9 | 0.478 | 0.011 | 0.770 | −0.784 | |
| GWAS | Cortical plate | 5 | 0.843 | −1.064 | 0.857 | −1.061 | |
| GWAS | Dorsal pallium | 1 | 0.412 | 0.150 | / | / | |
| GWAS | Dorsolateral prefrontal cortex | 9 | 0.665 | −0.459 | 0.893 | −1.256 | |
| RNA | Cortical plate | 5 | 0.001* | 16.062 | 0.156 | 1.041 | |
| RNA | Dorsal pallium | 1 | 0.001* | 14.102 | / | / | |
| RNA | Dorsolateral prefrontal cortex | 9 | 0.001* | 16.235 | 0.410 | 0.135 | |
| TWAS | Cortical plate | 5 | 0.954 | −1.566 | 0.960 | −1.669 | |
| TWAS | Dorsal pallium | 1 | 0.580 | −0.189 | / | / | |
| TWAS | Dorsolateral prefrontal cortex | 9 | 0.952 | −1.633 | 0.871 | −1.061 | |
| Height | Cortical plate | 5 | 0.674 | −0.473 | 0.393 | 0.036 | |
| Height | Dorsal pallium | 1 | 0.701 | −0.546 | / | / | |
| Height | Dorsolateral prefrontal cortex | 9 | 0.110 | 1.229 | 0.100 | 1.623 | |
| Microglial cell_3 | ATAC | Cortical plate | 60 | 0.916 | −1.336 | 0.074 | 1.400 |
| ATAC | Dorsal pallium | 1 | 0.668 | −0.496 | / | / | |
| ATAC | Dorsolateral prefrontal cortex | 99 | 0.023* | 2.136 | 0.318 | 0.512 | |
| GWAS | Cortical plate | 60 | 0.276 | 0.581 | 0.184 | 0.902 | |
| GWAS | Dorsal pallium | 1 | 0.298 | 0.493 | / | / | |
| GWAS | Dorsolateral prefrontal cortex | 99 | 0.507 | −0.043 | 0.465 | 0.201 | |
| RNA | Cortical plate | 60 | 0.955 | −1.625 | 0.652 | −0.386 | |
| RNA | Dorsal pallium | 1 | 0.936 | −1.287 | / | / | |
| RNA | Dorsolateral prefrontal cortex | 99 | 0.350 | 0.341 | 0.255 | 0.703 | |
| TWAS | Cortical plate | 60 | 0.534 | −0.139 | 0.335 | 0.504 | |
| TWAS | Dorsal pallium | 1 | 0.325 | 0.450 | / | / | |
| TWAS | Dorsolateral prefrontal cortex | 99 | 0.793 | −0.793 | 0.804 | −0.862 | |
| Height | Cortical plate | 60 | 0.525 | −0.098 | 0.948 | −1.813 | |
| Height | Dorsal pallium | 1 | 0.739 | −0.646 | / | / | |
| Height | Dorsolateral prefrontal cortex | 99 | 0.999 | −2.942 | 0.508 | 0.015 | |
| Oligodendrocyte | ATAC | Cortical plate | 3 | 0.131 | 1.150 | 0.181 | 1.271 |
| progenitor cell | ATAC | Dorsolateral prefrontal cortex | 107 | 0.001* | 3.592 | 0.037* | 1.865 |
| GWAS | Cortical plate | 3 | 0.684 | −0.499 | 0.683 | −1.434 | |
| GWAS | Dorsolateral prefrontal cortex | 107 | 0.739 | −0.636 | 0.308 | 0.454 | |
| RNA | Cortical plate | 3 | 0.907 | −1.311 | 0.331 | −0.267 | |
| RNA | Dorsolateral prefrontal cortex | 107 | 0.014* | 2.428 | 0.429 | 0.183 | |
| TWAS | Cortical plate | 3 | 0.473 | 0.048 | 0.507 | −0.036 | |
| TWAS | Dorsolateral prefrontal cortex | 107 | 0.980 | −2.025 | 0.451 | 0.050 | |
| Height | Cortical plate | 3 | 0.205 | 0.820 | 0.843 | −1.350 | |
| Height | Dorsolateral prefrontal cortex | 107 | 0.379 | 0.310 | 0.910 | −1.369 | |
| ADCY1 group | ATAC | Dorsolateral prefrontal cortex | 30 | 0.001* | 4.472 | 0.136 | 1.174 |
| GWAS | Dorsolateral prefrontal cortex | 30 | 0.041* | 1.832 | 0.435 | 0.1 | |
| RNA | Dorsolateral prefrontal cortex | 30 | 0.176 | 0.961 | 0.094 | 1.313 | |
| TWAS | Dorsolateral prefrontal cortex | 30 | 0.491 | 0.053 | 0.507 | −0.05 | |
| HEIGHT | Dorsolateral prefrontal cortex | 30 | 0.717 | −0.589 | 0.779 | −0.743 |
Height was included as a negative control trait.
ATAC-seq assay for transposase-accessible chromatin using sequencing, GWAS genome-wide association study, TWAS transcriptome-wide association study. N_cell the number of cells contained in the subgroup. * indicates P < 0.05.