Table 3.
Top 3 clusters of the top 300 genes associated with bipolar disorder in four omics panels.
| Panel | GO | Category | Description | Count (%) | P-value | q-value |
|---|---|---|---|---|---|---|
| BD_ATAC | GO:1901702 | GO Molecular Functions | Salt transmembrane transporter activity | 34 (12.06) | 1.86E-17 | 4.17E-13 |
| GO:0097447 | GO Cellular Components | Dendritic tree | 33 (11.7) | 8.13E-16 | 9.12E-12 | |
| GO:0098794 | GO Cellular Components | Postsynapse | 29 (10.28) | 5.50E-12 | 1.07E-08 | |
| BD_GWAS | GO:0098793 | GO Cellular Components | Presynapse | 24 (8.63) | 6.76E-10 | 9.12E-06 |
| GO:0097060 | GO Cellular Components | Synaptic membrane | 20 (7.19) | 8.13E-10 | 9.12E-06 | |
| GO:0030424 | GO Cellular Components | Axon | 24 (8.63) | 6.17E-09 | 4.27E-05 | |
| BD_RNASeq | GO:0006954 | GO Biological Processes | Inflammatory response | 52 (17.93) | 1.48E-35 | 2.69E-31 |
| GO:0001775 | GO Biological Processes | Cell activation | 57 (19.66) | 2.40E-35 | 2.69E-31 | |
| GO:0050865 | GO Biological Processes | Regulation of cell activation | 53 (18.28) | 3.72E-33 | 2.82E-29 | |
| BD_TWAS | GO:0099568 | GO Cellular Components | Cytoplasmic region | 13 (4.71) | 2.95E-06 | 2.75E-02 |
| GO:0099111 | GO Biological Processes | Microtubule-based transport | 11 (3.99) | 3.39E-06 | 2.75E-02 | |
| GO:0030424 | GO Cellular Components | Axon | 19 (6.88) | 6.92E-06 | 3.80E-02 |
GO gene ontology, ATAC-seq assay for transposase-accessible chromatin using sequencing, GWAS genome-wide association study, TWAS transcriptome-wide association study.