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. 2024 Mar 28;27(3):397–410. doi: 10.1007/s10456-024-09914-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Vascular mimicry inhibitor CVM-1118 causes macrophage reduction in the regenerating fin. MΦ appearance during normal fin regeneration (a) versus CVM-1118-treated group (b) at 7dpa and their quantification during the period of 15 days (c); n = 100. In the treated group, MΦs surrounding the blood vessels and their presence at the front of the vessel tips appear lacking (b); the amount of MΦ is significantly reduced (about 60%) for the entire course of the experiment (c), which indicates that the vascular mimicry inhibitor CVM-1118 has a cytotoxic effect on MΦs as well. Images are acquired by confocal microscopy; green – ECs, red – MΦs (transgenic zebrafish line)