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. 2024 Jul 24;15:1417437. doi: 10.3389/fendo.2024.1417437

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Copyright © 2024 Carroll, Miller, Fuhr, Elsakr, Ricciardi, Del Bene, Stephens, Krystofiak, Lindsley, Kirigiti, Takahashi, Dean, Wesolowski, McCurdy, Friedman, Aagaard, Kievit and Gannon

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NKX6.1 expression in 1-year-old NHP offspring islets. (A) Representative images of NKX6.1 expression in islets of one year old NHP offspring of dams fed a control diet (CD) or a Western-style diet (WSD). (B) Percentage of insulin-positive cells in offspring islets that express MAFB. (C) Integrated intensity of NKX6.1 signal in insulin-positive cell nuclei. Open symbols denote female offspring. C/W: dam control diet/offspring Western-style diet; W/W: dam Western-style diet/offspring Western-style diet. C/W: n=3 (2M, 1F); W/W: n=5(2M, 3F). Scale bars = 20 μm.