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. 2024 Jul 24;15:1417437. doi: 10.3389/fendo.2024.1417437

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Copyright © 2024 Carroll, Miller, Fuhr, Elsakr, Ricciardi, Del Bene, Stephens, Krystofiak, Lindsley, Kirigiti, Takahashi, Dean, Wesolowski, McCurdy, Friedman, Aagaard, Kievit and Gannon

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Urocortin-3 expression in 1-year-old NHP islets. (A) Representative images of UCN3 expression in islets of one year old NHP offspring of dams fed a control diet (CD) or a Western-style diet (WSD). (B) Percentage of insulin-positive cells in offspring islets that express UCN3 and (C) the intensity of UCN3 in insulin-positive cells. (D) Expression of UCN3 in glucagon-positive cells and (E) the intensity of UCN3 in glucagon-positive cells. Open symbols denote female offspring. C/W: dam control diet/offspring Western-style diet; W/W: dam Western-style diet/offspring Western-style diet. C/W: n=4 (2M, 2F); W/W: n=4(2M, 2F). Scale bars = 20 μm.