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. 2024 Jul 24;15:1417437. doi: 10.3389/fendo.2024.1417437

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Copyright © 2024 Carroll, Miller, Fuhr, Elsakr, Ricciardi, Del Bene, Stephens, Krystofiak, Lindsley, Kirigiti, Takahashi, Dean, Wesolowski, McCurdy, Friedman, Aagaard, Kievit and Gannon

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mitochondrial morphology in beta cells of 1-year-old NHP. (A) Micrograph depicting mitochondria (pseudo-colored blue) in the beta cell of a 1-year-old offspring from a control diet-fed dam. Representative insulin granule shown with purple arrow. (B) Micrograph depicting mitochondria (pseudo-colored blue) in the beta cell of a 1-year-old offspring from a Western-style diet-fed dam. Representative insulin granule shown with purple arrow. (C) Circularity of segmented mitochondria in 1-year-old beta cells (D) Perimeter of mitochondria in 1-year-old NHP beta cells. (E) Feret’s diameter of beta-cell mitochondria in 1-year-old offspring islets. (F) Aspect ratio of mitochondria in 1-year-old offspring beta cells. C/W: dam control diet/offspring Western-style diet; W/W: dam Western-style diet/offspring Western-style diet. C/W: n=13 (9M, 4F); W/W: n=8(5M, 3F).