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. 2024 Jul 24;15:1417437. doi: 10.3389/fendo.2024.1417437

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Copyright © 2024 Carroll, Miller, Fuhr, Elsakr, Ricciardi, Del Bene, Stephens, Krystofiak, Lindsley, Kirigiti, Takahashi, Dean, Wesolowski, McCurdy, Friedman, Aagaard, Kievit and Gannon

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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3-dimensional deconvolution of the mitochondrial network in 3-year-old NHP beta cells. (A) Representative image depicting beta cells from a 3-year-old offspring of a control diet-fed dam. Right inset depicts a volume rendering from a representative beta cell (white dashed circle). Mitochondria are color coded based on sphericity. (B) Representative image depicting beta cell from a 3-year-old offspring of a Western-style diet-fed dam. Right inset depicts a volume rendering from a representative beta cell (white dashed circle). Mitochondria are color coded based on sphericity. (C) Average sphericity of mitochondria in non-human primate beta cells. (D) Mitochondrial volume in beta cells of 3-year-old NHP offspring. (E) Volume of mitochondria in offspring beta cells characterized as fragmented (sphericity >0.45). (F) Comparison of total beta-cell mitochondrial volume in 3-year-old NHP offspring relative to 1-year-old offspring. C/W: dam control diet/offspring Western-style diet; W/W: dam Western-style diet/offspring Western-style diet. C/W: n=4 (2M, 2F); W/W: n=4(2M, 2F). Scale bars = 4 μm. p-values are depicted above pairwise comparisons.