Table 2.

The utilization of cyanobacteria and their bioactive compounds in the field of biomedicine. (N/A, not available).

Species	Properties	Model	Diseases	Test strategy	Doses	Ref.
Aurantiochytrium	Anti-inflammatory	Mice	Neuroinflammation	Oral	100 mg/kg	[59]
Arthrospira platensis, Dunaliella Salina	Anti-cancer	Hamster	Tumors	Injection	350 μg/0.3 mL	[139]
Spirulina platensis	N/A	Rats	Liver injury	Liver perfusion	0.1 and 0.2 mg/ml/g of liver	[140]
S. platensis	Anti-cancer	Rats	Colon cancer	Oral	200 mg/kg	[141]
S. platensis	Anti-inflammatory	Mice	Colitis	Oral	150 mg/kg	[142]
Lyngbya majuscula	Anti-cancer	Mice	Breast cancer	Incubation, Injection	80 nM-3 μM, 10 mg/kg	[50,72]
Porphyridium	Anti-virus	Rats and rabbits	Herpes simplex viruses	Injection/scratching	100 μg/mL	[143]
Phormidium	Anti-inflammatory	Zebrafish	N/A	Incubation	6.25–100 μg/mL	[144]
Synechocystis	Toxicity	Zebrafish	N/A	Immersion trials	250 and 500 μg LPS/mL of EVs	[145]
Synechococcus elongatus	Wound healing	Mice	N/A	Injection	105 cells/100 μL	[103]
Chlorella vulgaris	Oxygen therapy	Mice	Cancer	Injection, Injection, Injection	106 cells/mL, 8 × 106 cells/mL, 107 cells/mL	[33] [146,147]
S. elongatus	Oxygen therapy	Mice	Myocardial injury	Injection	106 cells	[148]
S. elongatus	Oxygen therapy	Mice	Rheumatoid arthritis	Injection	108 cells	[149]
S. elongatus	Oxygen therapy	Rats	Anaerobic infectious keratitis and infected periodontitis	Hydrogel	4 × 107 cells/mL	[150]
C. reinhardtii Synechocystis	Oxygen therapy	Xenopus laevis tadpoles	Neuronal hypoxia	Injection	1010 cells/mL	[151]
C. pyrenoidosa	Oxygen therapy/wound healing	Mice	Diabetic wounds	Hydrogel	105-107 cells/mL	[152]
C. vulgaris	Heavy metal biosorption	Mice	Lead poisoning	Gavage	8 mg/mL	[153]
S. elongatus	Provide carbon source	Rats	Skin defect	Hydrogel	1.5 × 108 cells/mL	[154]
S. platensis	Drug delivery	Mice	Diabetic wounds	Hydrogel	800 μg/mL	[155]
S. platensis	Drug delivery	Mice	Cancer	Injection	500 μg (DCW)	[156]
S. platensis	Drug delivery	Mice	Radiation-induced injury	Oral	0.5 mg/mL	[157]