Table 1. Drug Coformer Miscibility Calculation Using the Hildebrand and Hansen Solubility Parameter Method.
s.no. | substance | molecular weight (g/mol) | density (g/cm3) | molecular volume (cm3/mol) | melting point (K) | ΔH fusion (kJ/mol) | solubility
parameter (MPa1/2) |
|||
---|---|---|---|---|---|---|---|---|---|---|
Hildebrand | Hansen |
|||||||||
δd | δp | δh | ||||||||
1 | ceritinib38 | 558.14 | 1.3 ± 0.0.1 | 423.18 | 442.14 | 15.13 | 32.78 | 14.48 | 4.23 | 8.13 |
2 | naringin45 | 580.54 | 1.5 ± 0.0.1 | 372.14 | 440.15 | 2.09 | 30.63 | 18.21 | 12.02 | 21.69 |