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. 2024 Jul 25;21(8):3951–3966. doi: 10.1021/acs.molpharmaceut.4c00303

Table 1. Drug Coformer Miscibility Calculation Using the Hildebrand and Hansen Solubility Parameter Method.

s.no. substance molecular weight (g/mol) density (g/cm3) molecular volume (cm3/mol) melting point (K) ΔH fusion (kJ/mol) solubility parameter (MPa1/2)
              Hildebrand Hansen
                δd δp δh
1 ceritinib38 558.14 1.3 ± 0.0.1 423.18 442.14 15.13 32.78 14.48 4.23 8.13
2 naringin45 580.54 1.5 ± 0.0.1 372.14 440.15 2.09 30.63 18.21 12.02 21.69