Table 3. Pharmacokinetic Characteristics Following a Single Oral Dose (15 mg/kg) of CRT, CNPM, and CAMs (n = 3).
| s.no. | parameter | CRT | CNPM | CRT/NRG 1:1 | CRT/NRG 1:2 | CRT/NRG 2:1 |
|---|---|---|---|---|---|---|
| 1 | AUC0–t (ng h/mL) | 3584.63 ± 217.65 | 3830.92 ± 870.41 | 4699.30 ± 1086.10 | 4309.61 ± 488.75 | 8793.96 ± 171.08a |
| 2 | Cmax (ng/mL) | 173.26 ± 5.34 | 186.55 ± 30.67 | 220.62 ± 115.34 | 210.12 ± 14.90 | 419.28 ± 18.13a |
| 3 | Tmax (h) | 6 | 6 | 6 | 6 | 6 |
| 4 | t1/2 (h) | 22.13 | 26.88 | 18.40 | 20.15 | 17.54 |
| 5 | MRT (h) | 20.19 ± 0.75 | 19.25 ± 1.34 | 18.85 ± 5.99 | 19.77 ± 1.93 | 21.35 ± 1.18 |
a
A substantial difference when compared to the control (CNPM). p < 0.05 significantly different.