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The ISP protects mice from lethal EMCV infection. Groups of 10 mice were injected i.p. with PBS, 1 μg of murine IFN-γ, 1 μg of IFN-αA/D, or one of two concentrations of ISP (0.7 or 7 μg) 20 and 1 h prior to a single lethal dose of EMCV (2 × 104 PFU). Hind limb paralysis was monitored for 23 days postinfection.
