Figure 3.

H1N1 influenza virus-induced IFN-β alters the fecal microbiota diversity and composition; analysis of the fecal microbiota from the control, virus-infected mice, and antibiotic-treated mice during influenza infection. (A) The diversity of fecal microbiota from experimental groups on the 9th day post infection (dpi) was analyzed by sequencing; (B) Graph is the average relative abundance of each bacterial phylum; (C, D) LDA score about control and virus infection group, control, and antibiotic-treated group. Con: Female BALB/c mice aged 6 to 7 weeks (20 ± 2 g) were treated with PBS; Inf group: Female BALB/c mice aged 6 to 7 weeks (20 ± 2 g) were treated with influenza virus infection; Ant group: Female BALB/c mice aged 6 to 7 weeks (20 ± 2 g) were treated with combination of antibiotics.