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. 2024 Jun 27;15(31):12284–12290. doi: 10.1039/d4sc02981j

Ligand stoichiometry effects on the tandem Larock/Buchwald–Hartwig annulation/cyclization.

graphic file with name d4sc02981j-u2.jpg
Entry Dt-BPF mol% XPhos mol% Yielda (%)
1 30 0 3
2 25 5 8
3 20 10 10
4 15 15 72
5 10 20 64
6 5 25 47
7 0 30 36
a

Yields were determined by LC/MS using 1,3,5-trimethoxy benzene as an internal standard.