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. 2024 Aug 7;22:317. doi: 10.1186/s12916-024-03536-3

Table 3.

Threshold effect analysis of NHHR on all-cause and CVD mortality in participants with diabetes or prediabetes

Adjusted HR (95%CI), P value
All-cause mortality
 Total 1.03 (0.99, 1.08) 0.104
Segmented cox proportional hazards model
 Inflection point 2.72
 NHHR < 2.72 0.76 (0.68, 0.85) 0.001
 NHHR ≥ 2.72 1.11 (1.06, 1.16) 0.001
 P for Log-likelihood ratio  < 0.001
CVD mortality
 Total 0.98 (0.90, 1.06) 0.568
Segmented cox proportional hazards model
 Inflection point 2.83
 NHHR < 2.83 0.70 (0.57, 0.85) 0.001
 NHHR ≥ 2.83 1.08 (1.00, 1.16) 0.027
 P for Log-likelihood ratio 0.001

The model was adjusted for sex, age, race, education, marital status, poverty income ratio, BMI, smoking status, drinking status, physical activity, hypertension, hyperlipidemia, antihyperglycemic treatment, lipid-lowering treatment, and antihypertensive treatment

 BMI Body mass index, CI Confidence interval, CVD Cardiovascular disease, HR Hazard ratio