Table 3.
Univariate results for the surgically confirmed recurrent endometriosis analysis using ultrasound data
| Non-endometriosis control | Single endometriosis diagnosis | Recurrent endometriosis | Non-endometriosis control vs recurrent endometriosis | Non-endometriosis control vs single endometriosis diagnosis | Single endometriosis diagnosis vs recurrent endometriosis | ||||
|---|---|---|---|---|---|---|---|---|---|
| Univariate analysis | |||||||||
| OR, 95% CI | p value | OR, 95% CI | p value | OR, 95% CI | p value | ||||
| Uterine volume (ml) | |||||||||
| n | 67 | 105 | 63 | ||||||
| Mean (range) | 69.70 (16.00–308.40) | 67.00 (23.00–213.00) | 85.81 (23.20–370.00) | 0.119 | 0.672 | 0.017 | |||
| Under 40 ml | 16 (23.9) | 14 (13.3) | 5 (7.9) | ||||||
| 40–110 ml | 44 (65.7) | 82 (78.1) | 45 (71.4) | 3.27 (1.10–9.70) | 0.033 | 2.13 (0.95–4.77) | 0.066 | 1.54 (0.52–4.54) | 0.437 |
| > 110 ml | 7 (10.4) | 9 (8.6) | 13 (20.6) | 5.94 (1.52–23.18) | 0.010 | 1.47 (0.43–4.98) | 0.537 | 4.04 (1.07–15.27) | 0.039 |
| Log uterine volume (ml) | |||||||||
| n | 67 | 105 | 63 | ||||||
| Mean (range) | 1.77 (1.20–2.49) | 1.79 (1.36–2.33) | 1.87 (1.37–2.57) | 0.023 | 0.460 | 0.021 | |||
| Uterine position | |||||||||
| Anteverted | 59 (90.8) | 83 (79.8) | 48 (77.4) | – | |||||
| Retroverted | 6 (9.2) | 20 (19.2) | 12 (19.4) | 2.46 (0.86–7.04) | 0.094 | 2.37 (0.90–6.26) | 0.082 | 1.04 (0.47–2.31) | 0.928 |
| Axial | 0 (0.0) | 1 (1.0) | 2 (3.2) | N/A | N/A | 3.46 (0.31–39.15) | 0.316 | ||
| Fibroids present | |||||||||
| No (n, %) | 63 (88.7) | 103 (88.8) | 54 (79.4) | ||||||
| Yes (n, %) | 8 (11.3) | 13 (11.2) | 14 (20.6) | 2.04 (0.80–5.24) | 0.137 | 0.99 (0.39–2.53) | 0.990 | 2.05 (0.90–4.68) | 0.087 |
| No. of fibroids | |||||||||
| n | 71 | 116 | 68 | ||||||
| Mean (range) | 0.23 (0–5) | 0.13 (0–2) | 0.34 (0–4) | 0.421 | 0.294 | 0.034 | |||
| Volume of largest fibroid (ml) | |||||||||
| n | 6 | 11 | 11 | ||||||
| Mean (range) | 58.62 (0.40–174.00) | 2.89 (0.10–8.00) | 27.74 (0.60–246.50) | 0.414 | 0.148 | 0.188 | |||
| Ovarian cysts present | |||||||||
| No (n, %) | 54 (76.1) | 77 (66.4) | 41 (60.3) | ||||||
| Yes (n, %) | 17 (23.9) | 39 (33.6) | 27 (39.7) | 2.09 (1.01–4.34) | 0.048 | 1.61 (0.83–3.14) | 0.163 | 1.30 (0.70–2.42) | 0.407 |
| No. of ovarian cysts | |||||||||
| n | 71 | 116 | 68 | ||||||
| Mean (range) | 0.34 (0–4) | 0.67 (0–10) | 0.62 (0–3) | 0.047 | 0.078 | 0.773 | |||
| Polycystic ovaries present | |||||||||
| No (n, %) | 61 (85.9) | 101 (87.1) | 65 (95.6) | ||||||
| Yes (n, %) | 10 (14.1) | 15 (12.9) | 3 (4.4) | 0.28 (0.07–1.07) | 0.063 | 0.91 (0.38–2.14) | 0.822 | 0.31 (0.09–1.12) | 0.073 |
| Adenomyosis present | |||||||||
| No (n, %) | 66 (93.0) | 92 (79.3) | 51 (75.0) | ||||||
| Yes (n, %) | 5 (7.0) | 24 (20.7) | 17 (25.0) | 4.40 (1.52–12.73) | 0.006 | 3.44 (1.25–9.49) | 0.017 | 1.28 (0.63–2.60) | 0.498 |
| Adenomyosis linear striations present | |||||||||
| No (n, %) | 68 (95.8) | 105 (90.5) | 62 (91.2) | ||||||
| Yes (n, %) | 3 (4.2) | 11 (9.5) | 6 (8.8) | 2.19 (0.53–9.15) | 0.281 | 2.37 (0.64–8.82) | 0.197 | 0.92 (0.33–2.62) | 0.882 |
| Adenomyosis heterogeneous myometrium | |||||||||
| No (n, %) | 71 (100.0) | 111 (95.7) | 61 (89.7) | ||||||
| Yes (n, %) | 0 (0.0) | 5 (4.3) | 7 (10.3) | N/A | N/A | 2.55 (0.78–8.37) | 0.123 | ||
| Adenomyosis thickened posterior wall | |||||||||
| No (n, %) | 68 (95.8) | 105 (90.5) | 61 (89.7) | ||||||
| Yes (n, %) | 3 (4.2) | 11 (9.5) | 7 (10.3) | 2.60 (0.64–10.51) | 0.180 | 2.37 (0.64–8.82) | 0.197 | 1.10 (0.40–2.97) | 0.858 |
| Endometriosis present (including OMA) | |||||||||
| No (n, %) | 69 (97.2) | 84 (72.4) | 40 (58.8) | ||||||
| Yes (n, %) | 2 (2.8) | 32 (27.6) | 28 (41.2) | 24.15 (5.46–106.78) | < 0.001 | 13.14 (3.04–56.80) | 0.001 | 1.84 (0.98–3.46) | 0.059 |
| Endometriosis present (excluding OMA) | |||||||||
| No (n, %) | 69 (97.2) | 112 (96.6) | 56 (82.4) | ||||||
| Yes (n, %) | 2 (2.8) | 4 (3.4) | 12 (17.6) | 7.39 (1.59–34.41) | 0.011 | 1.23 (0.22–6.91) | 0.812 | 6.00 (1.85–19.45) | 0.003 |
| Bilateral endometriomas | |||||||||
| No (n, %) | 71 (100.0) | 107 (92.2) | 63 (92.6) | ||||||
| Yes (n, %) | 0 (0.0) | 9 (7.8) | 5 (7.4) | N/A | N/A | 0.94 (0.30–2.94) | 0.920 | ||
| Adhesions (ultrasound) | |||||||||
| No (n, %) | 70 (98.6) | 110 (94.8) | 53 (77.9) | ||||||
| Yes (n, %) | 1 (1.4) | 6 (5.2) | 15 (22.1) | 19.81 (2.54–154.74) | 0.004 | 3.82 (0.45–32.39) | 0.219 | 5.19 (1.91–14.13) | 0.001 |
OMA Endometrioma