TABLE 3.

Estimation of the nucleotide substitution rate in the VP1 region of EV71

Data set	Substitution rate (substitutions/nt/yr)a
	Synonymous sites	(R2)	All sites	(R2)
B1b	1.6 × 10−2	(0.74)	4.2 × 10−3	(0.68)
C1c	1.2 × 10−2	(0.85)	3.4 × 10−3	(0.73)
Avgd	1.35 × 10−2		3.71 × 10−3

^aR², linear regression coefficient; nt, nucleotide. 

^bTwenty-five isolates, 1972 to 1987. 

^cThirty-nine isolates, 1986 to 1987. 

^dWeighted average for sets B1 and C1.