Fig. 3.

Cartilage at posterior medial condyles displays histopathological features of OA (A) Representative images displaying cartilage with the average (8 - left panel), lowest (6 - middle panel) and highest (12, right panel) Mankin score. Tidemark duplication was a common feature at posterior medial condyles (arrowheads). Superficial and transitional cartilage zone are indicated. (B–D) Scatter plot of maximum cartilage thickness ex vivo versus Mankin score, chondrocyte density and Apoptag-positive cells. Superficial and transitional zones of cartilage were defined as the ten percent volume fraction beneath the articular surface and superficial zone, respectively. Regression lines are depicted for superficial and transitional zones.