Table 3.

Univariate and Multivariable Cox Regression Analysis of Mitral Valve Reoperation Using 3D Echo Variables

3D Echo Variable	Univariate Cox Analysis				Multivariable Cox Analysis
	N	HR	(95% CI)	P Value	Adjusted HR	(95% CI)	P Value
Mitral stenosis and mixed disease patients
Size of 3D-EOA preoperatively	50	2.79	(1.48-5.25)	0.002a
Size of 3D-EOA postoperatively	49	0.69	(0.35-1.36)	0.283
Change of the 3D-EOA	39	0.27	(0.12-0.59)	0.001a	0.24	(0.06-0.9)	0.034a
Size of 3D-VCRA postoperatively	25	1.42	(1.06-1.90)	0.018a
Change of 3D-VCRA	18	2.52	(1.16-5.48)	0.020a	2.53	(1.15-5.6)	0.021a
Mitral regurgitation and mixed disease patients
Size of 3D-EOA postoperatively	30	0.80	(0.39-1.64)	0.536
Change of 3D-EOA	30	0.96	(0.32-2.82)	0.930
Size of 3D-VCRA preoperatively	38	1.81	(1.19-2.74)	0.005a
Size of 3D-VCRA postoperatively	30	3.15	(1.86-5.36)	<0.001a
Change of 3D-VCRA	30	15.7	(4.65-53.00)	<0.001a	11.5	(3.01-44.5)	<0.001a
Size of the 3D annulus preoperatively	45	1.03	(0.91-1.17)	0.649
Size of the 3D annulus postoperatively	30	1.16	(0.98-1.39)	0.086
Change in 3D annulus size	29	4.24	(1.00-18.3)	0.050a	1.95	(0.29-13.6)	0.511

Factors found to be statistically significant at univariate analysis were included in the multivariable model. Multivariable analysis for patients with mitral stenosis and mixed disease: n = 18 (no. of events = 11). Multivariable analysis for patients with mitral regurgitation and mixed disease: n = 25 (no. of events = 13).

3D-EOA = 3D effective orifice area; 3D-VCRA = 3D vena contracta regurgitant area.

^aStatistically significant.