Fig. 5.

Developmental profile of marker gene expression for pancreatic acinar cells, pancreatic duct cells, stromal cells and endocrine cells in WT and CFTR^−/− sheep pancreas. Normalized read counts from bulk RNA-seq data show gene expression through gestation at 65-, 80-, 100-, 120-days gestation and at term in WT and CFTR^−/− sheep. A–C acinar cell markers PRSS2, CEL and CELA3B; (D–F) pancreatic duct epithelial cell markers ELF5, KRT19 and CFTR; (G–I) markers of stromal cells DCN, COL1A1, COL3A1; (J, K) markers of endocrine cells SCGN and ISL1. WT values are shown has black circles and CFTR^−/− values as grey squares