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. 2024 Aug 7;23:287. doi: 10.1186/s12933-024-02386-w

Fig. 2.

Fig. 2

New-onset diabetes mellitus (NODM) among the patients who received a high-intensity statin according to the statin type.  (A) The incidence of NODM in overall patients receiving high-intensity statin therapy. (B) Cubic spline analysis of the risk of NODM in the rosuvastatin group versus atorvastatin group according to the achieved LDL-C levels. (C) The incidence of NODM in the patients with achieved LDL-C levels < 70 mg/dL. (D) The incidence of NODM in the patients with achieved LDL-C levels ≥ 70 mg/dL. From the cubic spline analysis plotting (B), an increase of NODM in the rosuvastatin group versus atorvastatin group began below an achieved LDL-C level of 70 mg/dL (red arrow), which was determined as a cut-off value. CI = confidence interval; HR = Hazard ratio; LDL-C = low-density lipoprotein cholesterol