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. Author manuscript; available in PMC: 2024 Aug 7.
Published in final edited form as: N Engl J Med. 2024 May 19;390(22):2083–2097. doi: 10.1056/NEJMsa2311809

Table 3.

Extrapolated Changes in Outcomes Calculated from Race-Based and Race-Neutral Lung-Function Equations, According to Persons Affected and Disability Payments in the United States.*

Outcome Net Change Total Change
Overall Asian or Other Black Hispanic White Overall Newly Classified No Longer Classified
Persons affected — no., in thousands (95% CI)
Obstructive impairment 2070 (1330 to 2820) −392 (−608 to −177) 110 (−17 to 237) 349 (231 to 466) 2010 (1360 to 2650) 3200 (2630 to 3860) 2640 (2080 to 3290) 565 (338 to 884)
Nonobstructive impairment −4700 (−6140 to −3270) −304 (−498 to −110) 2340 (1930 to 2750) −1370 (−1800 to −942) −5370 (−6550 to −4190) 9620 (8570 to 10,800) 2460 (1960 to 3040) 7160 (6130 to 8320)
Moderate-to-severe COPD: GOLD grade ≥2 −749 (−1180 to −316) 6 (−15 to 27) 428 (300 to 556) −85 (−139 to −32) −1100 (−1480 to −715) 1660 (1300 to 2070) 453 (324 to 617) 1200 (857 to 1640)
Occupational disqualification from firefighting −624 (−1200 to −48) 72 (10 to 135) 754 (540 to 969) −181 (−262 to −100) −1270 (−1730 to −809) 2280 (1840 to 2780) 826 (601 to 1110) 1450 (1030 to 1980)
Moderate-to-severe impairment: AMA class ≥2 −297 (−725 to 131) 41 (−9 to 92) 638 (478 to 797) −38 (−59 to −16) −938 (−1310 to −570) 1580 (1250 to 1960) 646 (481 to 849) 929 (632 to 1320)
Annual VA disability payments — U.S. $, in millions (95% Cl) 806 (−42 to 1,650) 279 (−268 to 825) 1,100 (585 to 1,610) 46 (−99 to 7) −524 (−917 to −131) 1,940 (1,100 to 2,790) 1,380 (627 to 2,120) 570 (173 to 966)
*

Differences are shown for the total number of affected persons or disability payment dollars when criteria are calculated with the use of race-neutral GLI-Global equations as compared with race-based GLI-2012 equations. Data from NHANES IV were survey-adjusted to be representative of the U.S. population (see the Supplementary Methods section).