FIGURE 3.

Origin of the VDMs but not total VDM concentration play crucial role in the combinatory antagonistic effects against BTZ in gallotannins. RPMI 8226 cells were treated with the indicated concentrations of BTZ and polyphenols both alone and in combination for 72 h, then cell viability was measured by resazurin. (A) The antagonistic effects of 1,3,6-triGG and the combination of GA and 2′,6′-diGG against BTZ. (B) The antagonistic effects of PGG and the combination of 1,3,6-triGG and 2′,6′-diGG against BTZ. (C) The antagonistic effects of 1,3,6-triGG and PGG against BTZ. Data are presented as mean ± SD (n = 3). The (*) and (#) indicate a significant difference compared with the corresponding PGG alone group and 1,3,6-triGG alone group, respectively (p < 0.05, one-way ANOVA).