FIGURE 4.

The aromaticity of dietary polyphenols contributed to their antagonistic effect against BTZ. (A) ChemGPS-NP analysis of the structure-activity relationship of vicinal diol-containing dietary polyphenols. Twenty dietary polyphenols, including 15 dietary polyphenols, 4 analogs of quercetin and vitamin C (Table 1) were plotted into the three-dimensional graph consisting of PC1, PC2, PC3 in Apple™ system software Grapher 2.0. (B) The antagonistic potency against BTZ of LT and 2′,4′,6′,3,4-pentahydroxychalcone (PCC) was detected after 72 h by resazurin in RPMI 8226 cells. The data represent the mean ± SD (n = 3).