FIGURE 1.

Interplay between Mitochondria and Gut Microbiome. There is evidence that there is communication between the mitochondria and the microbiome. Mitochondrial function is dependent on an individual’s genetics (mitochondrial and nuclear DNA mutations, heterpolasmy levels and the haplotype) and environmental factors (diet, lifestyle and stress). In turn, these factors have the potential to alter microbial diversity, relative abundance and microbial metabolites produced. Similarly, the microbiome composition and lifestyle factors (diet, exercise, medications) modulate mitochondrial function. Created with BioRender.com.