TABLE 3.
Characteristics of the patients with RA and the differences between the ones without and with fatigue.
| Without fatigue (n: 75) |
With fatigue (n: 116) |
p | |
| Age (years) | 67.6 ± 10.0 | 67.3 ± 8.1 | ns |
| BMI (kg/m2) | 27.2 ± 5.7 | 28.3 ± 5.2 | ns |
| Underweight (n, %) | 0 (−) | 0 (−) | |
| Normal range (n, %) | 31 (41%) | 33 (28%) | |
| Overweight (n, %) | 21 (28%) | 51 (44%) | |
| Obese (n, %) | 23 (31%) | 32 (28%) | ns |
| Smoking (n: 188) | |||
| Never | 66 (90.4%) | 98 (85.2%) | |
| Ever | 1 (1.4%) | 1 (0.9%) | |
| Current | 6 (8.2%) | 16 (13.9%) | ns |
| Physical activity (n: 187) | |||
| None | 33 (45.2%) | 61 (53.5%) | |
| Sporadic | 11 (15.1%) | 25 (21.9%) | |
| Regular with low intensity | 27 (37.0%) | 28 (24.6%) | |
| Regular with high intensity | 2 (2.7%) | 0 (-) | ns |
| Albumin (g/L) | 44,1 ± 3,4 | 44,0 ± 3,5 | ns |
| Albumin < 35 g/L (n, %) | 2 (2.7%) | 2 (1.7%) | ns |
| Disease duration (years) | 17.1 ± 11.2 | 16.6 ± 9.8 | ns |
| RF + (n: 171) (n, %) | 50 (73%) | 72 (71%) | ns |
| RF titer (only RF+) (UI/L) | 144 ± 220 | 266 ± 531 | ns |
| ACPA + (n: 172) (n, %) | 46 (69%) | 76 (72%) | ns |
| ACPA titer (only ACPA+) (U/L) | 348 ± 616 | 386 ± 718 | ns |
| ESR (mm/h) | 20.6 ± 18.2 | 27.4 ± 22.0 | ns |
| CRP (mg/dL) | 4.5 ± 4.0 | 5.7 ± 7.1 | ns |
| Hemoglobin (g/dL) | 13.4 ± 1.2 | 13.3 ± 1.2 | ns |
| DAS28 | 2.5 ± 0.9 | 3.2 ± 1.1 | < 0.001 |
| Remission (n, %) | 44 (58%) | 33 (28%) | |
| LDA (n, %) | 17 (23%) | 30 (26%) | |
| MDA (n, %) | 14 (19%) | 47 (41%) | |
| HDA (n, %) | 0 (−) | 6 (5%) | < 0.001 |
| RAPID3 | 4.6 ± 3.8 | 12.6 ± 6.6 | < 0.001 |
| Remission (n, %) | 27 (46%) | 11 (11%) | |
| LDA (n, %) | 8 (14%) | 5 (5%) | |
| MDA (n, %) | 23 (39%) | 32 (32%) | |
| HDA (n, %) | 1 (1%) | 54 (54%) | < 0.001 |
| HAQ | 0.08 ± 0.19 | 0.22 ± 0.34 | < 0.01 |
| Current medication | |||
| Glucocorticoids (n, %) |
30 (40%) | 59 (51%) | ns |
| cDMARDs (n, %) | 70 (93%) | 102 (89%) | ns |
| bDMARDs (n, %) | 24 (32%) | 44 (38%) | ns |
| Jak inhibitors (n, %) | 2 (3%) | 8 (7%) | ns |
| SF-12 | |||
| Mental health | 50.9 ± 9.5 | 41.5 ± 11.0 | < 0.001 |
| Physical health | 43.5 ± 8.5 | 32.7 ± 7.5 | < 0.001 |
BMI, body mass index; RF, rheumatoid factor; ACPA, anti-citrullinated peptides antibodies; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; DAS28, Disease Activity Score 28; LDA, low disease activity; MDA, moderate disease activity; HDA, high disease activity; RAPID3, Routine Assessment of Patient Index Data 3; HAQ, Health Assessment Questionnaire; cDMARDs, conventional disease-modifying antirheumatic drugs; bDMARDs, biological disease-modifying antirheumatic drugs; SF-12, Short Form Health Survey-12.