Table 2.
Summary statistical analysis of the most reactive gonococcal antigens against IgA following vaccination with 4CMenB
| Label | Function | % identitya | NEIS | 4CMenB Recombinant?b | p valuec | Staged |
|---|---|---|---|---|---|---|
| NHBA | Heparin-binding protein | 68e | NEIS2109 | x | 9.69E-10 | t0:t10 |
| GNA2091 | Hemolysin/lipoprotein | 96e | NEIS2071 | x | 8.40E-09 | t0:t10 |
| PIII/RmpM | PorB stabilisation | 93 | NEIS1783 | 7.07E-04 | t0:t10 | |
| NGO0751 | Autochaperone domain-containing protein | -e | NEIS2658 | 1.33E-03 | t0:t10 | |
| GNA2091 | Hemolysin/lipoprotein | 96e | NEIS2071 | x | 2.62E-07 | t0:t24 |
| NHBA | Heparin-binding protein | 68e | NEIS2109 | x | 4.31E-07 | t0:t24 |
| NGO0690 | Lipoprotein | 86 | NEIS1164 | 1.69E-05 | t0:t24 | |
| PilN_domain | Type IV pilus assembly | 97 | NEIS0411 | 3.26E-05 | t0:t24 | |
| membrane protein 2 | Membrane-associated lipoprotein | 97 | NEIS1304 | 5.01E-05 | t0:t24 | |
| NGO1063 | Membrane-associated lysozyme inhibitor (MliC) | 92 | NEIS1425 | 7.92E-04 | t0:t24 | |
| NGO0834 | Curli pilus assembly (CsgG-like) | 96 | NEIS1066 | 1.40E-03 | t0:t24 | |
| HpuB | Haemoglobin-haptoglobin utilisation protein B | 94 | NEIS1947 | 1.48E-03 | t0:t24 | |
| NGO0891 | Lipoprotein | 95 | NEIS2666 | 1.75E-03 | t0:t24 | |
| ComP | Pilin-like protein; Natural competence | 99 | NEIS0899 | 3.57E-03 | t0:t24 | |
| membrane protein 1 | Lipoprotein; OmpA-like domain | -e | NEIS2704 | 9.36E-03 | t0:t24 |
a% identity between FA1090 protein as immobilised on the array slide (with the His tag removed) and the equivalent protein in the NZ Nm strain used in 4CMenB or closest equivalent in another strain.
bDenotes recombinant proteins in the 4CMenB formulation.
cCalculated using a one-sided Wilcoxon paired rank test with correction after Hommel67 listed in increasing order of p value. Only antigens with p < 0.01 are listed.
dPaired t0 with t10 or t0 with t24.
eNo close homologues in N. meningitidis.