Fig. 3.

Figure depicts two cases with unusual p16/p53 immunostaining results. Tumour tissue in case 2 shows mostly wildtype p53 staining pattern, with focal null-type staining; the tumour is p16 and HPV ISH negative, and two different TP53 mutations were detected on NGS. Tumour tissue in case 3 had diffuse p53 overexpression, variable, mostly cytoplasmic 16 positivity and was HPV ISH negative, with a TP53 mutation detected on NGS. Both cases were categorized as HPV-independent SCC