Table 1.

Effect of ZA (50 µg/kg/week) on MBP, kidney index, serum creatinine, BUN, uACR in a CCl₄ induced RF rat model.

	Control	Model-RF	RF-ZA
MBP (mmHg)	66 ± 2.1	24 ± 0.97***	63 ± 2.3###
Kidney index	0.62 ± 0.005	0.99 ± 0.072***	0.67 ± 0.039###
uACR	11 ± 0.39	37 ± 1.2***	14 ± 1.7###
Serum creatinine (nmol/ml)	2.1 ± 0.14	7.6 ± 0.90 ***	2.5 ± 0.72###
BUN (nmol/ml)	231 ± 4.6	676 ± 40***	251 ± 18###

Data are mean ± S.D. n = 10 rats per group.

ZA zoledronic acid, RF renal fibrosis, MBP mean blood pressure, uACR urinary albumin to creatinine ratio, BUN blood urea nitrogen.

***P < 0.0001 significant compared to control group.

^###P < 0.0001 significant compared to model-RF group by one-way ANOVA with Tukey’s multiple comparison test.