Table 2.
Effect of ZA (50 µg/kg/week) on MDA, catalase, TNF-α, TGF-β, FPP and expression of NF-kB and FPPS in kidney tissues of a CCl4 induced RF rat model.
| Control | Model- RF | RF-ZA | |
|---|---|---|---|
| MDA (nmol/mg) | 0.33 ± 0.03 | 1.5 ± 0.06*** | 0.41 ± 0.09### |
| Catalase (mU/mg) | 3.016 ± 0.204 | 0.938 ± 0.119*** | 2.725 ± 0.275### |
| TNF-α (pg/mg) | 29.2 ± 3.3 | 184 ± 24.8*** | 47.9 ± 4.57### |
| TGF-β (pg/mg) | 57.4 ± 3.2 | 336 ± 34.2*** | 61.6 ± 16.4### |
| FPP (ng/mg) | 215 ± 24 | 391 ± 16*** | 235 ± 32### |
| FPPS | 1.0 ± 0.01 | 5.6 ± 1.20*** | 1.3 ± 0.27### |
| NF-kB | 1.1 ± 0.1 | 8.7 ± 2.1*** | 1.2 ± 0.1### |
Data are mean ± S.D. n = 10 rats per group.
ZA zoledronic acid, RF renal fibrosis, MDA malondialdehyde, TNF-α tumor necrosis factor-alpha, TGF-β transforming growth factor-β, FPP farnesyl pyrophosphate, NFκB nuclear factor-κB, FPPS farnesyl pyrophosphate synthase.
***P < 0.0001 significant compared to control group.
###P < 0.0001 significant compared to model-RF group by one-way ANOVA with Tukey’s multiple comparison test.