Table 2.

Pharmacokinetic problems with oral L-DOPA and the value of continuous dopaminergic administration therapies in resolving these problems

The color code represents the degree of impact of pharmacological bias (essentially pharmacokinetic) on the dopaminergic strategy. Red: significant impact; orange: partial impact (because 50–70% of the oral treatment is maintained), with a light vs. dark gradation if it is significant; green: therapeutic strategy not affected, with a light vs. dark gradation if it is significant. PD, Parkinson’s disease; TDC, tyrosine decarboxylase; AADC, amino acid decarboxylase.