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The mean change in MMSE score over time. Significant difference in the average between the two groups of treatment at each time point (T1, 6 months and T2, 12 months; t-test with a 5% significance level). *p < 0.001 compared to controls (Wilcoxon-Rank Sum Tests to pairwise comparisons between group levels with Bonferroni’s corrections for multiple testing).
