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. 2024 Jul 26;48(4):546–708. doi: 10.4093/dmj.2024.0249
1. Screening for diabetes should be considered after the onset of puberty or ≥10 years of age in overweight or obese children with risk factors for diabetes. [Expert opinion, general recommendation]
2. Children and adolescents diagnosed with T2DM should initiate lifestyle modification and be educated by a team comprising experts, along with their families or caregivers. [Non-randomized controlled trial, general recommendation]
3. The HbA1c goal for children and adolescents with T2DM is <7.0%. [Expert opinion, general recommendation]
4. Initial pharmacologic therapy can be started with metformin monotherapy, insulin monotherapy, or a combination of both. [Expert opinion, general recommendation]
5. Immediate insulin therapy should be considered if ketosis/ketonuria/ketoacidosis is present, the HbA1c is ≥8.5%, or the blood glucose level is ≥250 mg/dL. [Expert opinion, general recommendation]
6. For children and adolescent diabetics without diabetes symptoms and an HbA1c level of <8.5%, treatment can be started with metformin alone. [Expert opinion, general recommendation]
7. If metformin alone does not achieve the glycemic goal, basal insulin should be used concomitantly. [Expert opinion, general recommendation]
8. If metformin and basal insulin treatment do not achieve the glycemic goal, MDIs or insulin pumps should be used. [Expert opinion, general recommendation]
9. Liraglutide can be administered to youth aged ≥12 years with T2DM who have a stage II or higher obesity (≥120% of the 95th percentile of BMI). [Randomized controlled trial, limited recommendation]
10. Poor glycemic control or presence of comorbidities in youth with T2DM who have a stage II or higher obesity (≥120% of the 95th percentile of BMI) may require bariatric surgery with considerations to the growth state of the youth. [Non-randomized controlled trial, limited recommendation]
11. For youth with T2DM, routine evaluation of comorbidities and microvascular complications is conducted starting at the time of diagnosis. [Other trial, general recommendation]
12. For youth with T2DM, routine assessments for depression, anxiety, eating disorders, sleep apnea, and sleep disorders should be conducted. [Uncontrolled studies, general recommendation]
13. Youth with T2DM should be transferred to an adult clinic at an appropriate time. [Expert opinion, general recommendation]