Table 3.
Unadjusted Effects of Demographics and Clinical Characteristics on Microscopic Colitis Diagnosis
| Variable | Microscopic colitis diagnosis |
OR (95% CI) | P | |
|---|---|---|---|---|
| Colitis (CC/LC) (%) | Incomplete colitis (CCi/LCi) (%) | |||
| 236 (89.06) | 29 (10.94) | - | - | |
| Sex | ||||
| Female | 191 (80.93) | 22 (75.86) | 1.35 (0.54, 3.36) | .52 |
| Male (REF) | 45 (19.07) | 7 (24.14) | ||
| Age (y) | ||||
| >50 | 212 (89.83) | 19 (65.52) | 4.65 (1.94, 11.15) | <.01a |
| <50 | 24 (10.17) | 10 (34.48) | ||
| Race | ||||
| Non-white | 25 (10.59) | 4 (14.29) | 0.71 (0.23, 2.21) | .56 |
| White (REF) | 211 (89.41) | 24 (85.71) | ||
| Hormonal therapy | ||||
| Yes | 35 (14.83) | 7 (24.14) | 0.55 (0.22, 1.38) | .20 |
| No (REF) | 201 (85.17) | 22 (75.86) | ||
| Smoking | ||||
| Yes | 127 (53.81) | 11 (37.93) | 1.91 (0.86, 4.21) | .11 |
| No (REF) | 109 (46.19) | 18 (62.07) | ||
| History of diarrhea | ||||
| Yes | 211 (89.41) | 26 (89.66) | 0.97 (0.27, 3.45) | .97 |
| No (REF) | 25 (10.59) | 3 (10.34) | ||
| Positive stool for pathogens | ||||
| Yes | 17 (7.20) | 1 (3.45) | 2.17 (0.28, 16.96) | .46 |
| No (REF) | 219 (92.80) | 28 (96.55) | ||
| Alcohol use | ||||
| Yes | 134 (56.78) | 12 (41.38) | 1.86 (0.85, 4.07) | .12 |
| No (REF) | 102 (43.22) | 17 (58.62) | ||
| Diabetes | ||||
| Yes | 44 (18.64) | 6 (20.69) | 0.88 (0.34, 2.29) | .79 |
| No (REF) | 192 (81.36) | 23 (79.31) | ||
| HLD | ||||
| Yes | 144 (61.02) | 13 (44.83) | 1.93 (0.89, 4.19) | .10 |
| No (REF) | 92 (38.98) | 16 (55.17) | ||
| CAD | ||||
| Yes | 61 (25.85) | 4 (13.79) | 2.18 (0.73, 6.51) | .16 |
| No (REF) | 175 (74.15) | 25 (86.21) | ||
| HTN | ||||
| Yes | 137 (58.05) | 14 (48.28) | 1.48 (0.68, 3.21) | .32 |
| No (REF) | 99 (41.95) | 15 (51.72) | ||
| IBS | ||||
| Yes | 28 (11.86) | 0 (0.00) | - | .05b |
| No (REF) | 208 (88.14) | 29 (100.00) | ||
| Thyroid disease | ||||
| Yes | 63 (26.69) | 3 (10.34) | 3.15 (0.92, 10.78) | .07 |
| No (REF) | 173 (73.31) | 26 (89.66) | ||
| Celiac disease | ||||
| Yes | 12 (5.08) | 0 (0.00) | - | .37b |
| No (REF) | 224 (94.92) | 29 (100.00) | ||
| Autoimmune disease | ||||
| Yes | 27 (11.44) | 4 (13.79) | 0.81 (0.26, 2.50) | .71 |
| No (REF) | 209 (88.56) | 25 (86.21) | ||
| Probiotics | ||||
| Yes | 67 (28.39) | 8 (27.59) | 1.04 (0.44, 2.46) | .93 |
| No (REF) | 169 (71.61) | 21 (72.41) | ||
| NSAIDs | ||||
| Yes | 107 (45.34) | 16 (55.17) | 0.67 (0.31, 1.46) | .32 |
| No (REF) | 129 (54.66) | 13 (44.83) | ||
| Anticonvulsants | ||||
| Yes | 14 (5.93) | 2 (6.90) | 0.85 (0.18, 3.95) | .84 |
| No (REF) | 222 (94.07) | 27 (93.10) | ||
| Statins | ||||
| Yes | 129 (54.66) | 11 (37.93) | 1.97 (0.89, 4.36) | .09 |
| No (REF) | 107 (45.34) | 18 (62.07) | ||
| PPI | ||||
| Yes | 95 (40.25) | 13 (44.83) | 0.83 (0.38, 1.80) | .64 |
| No (REF) | 141 (59.75) | 16 (55.17) | ||
| No (REF) | 135 (57.20) | 16 (55.17) | ||
| SSRIs | ||||
| Yes | 86 (36.44) | 8 (27.59) | 1.50 (0.64, 3.54) | .35 |
| No (REF) | 150 (63.56) | 21 (72.41) | ||
| Tricyclic antidepressants | ||||
| Yes | 23 (9.75) | 2 (6.90) | 1.46 (0.33, 6.53) | .62 |
| No (REF) | 213 (90.25) | 27 (93.10) | ||
| Aspirin | ||||
| Yes | 120 (50.85) | 8 (27.59) | 2.72 (1.16, 6.37) | .02a |
| No (REF) | 116 (49.15) | 21 (72.41) | ||
| Beta-blocker | ||||
| Yes | 91 (38.56) | 5 (17.24) | 3.01 (1.11, 8.17) | .03a |
| No (REF) | 145 (61.44) | 24 (82.76) | ||
| Plavix | ||||
| Yes | 30 (12.71) | 2 (6.90) | 1.97 (0.44, 8.69) | .37 |
| No (REF) | 206 (87.29) | 27 (93.10) | ||
| H2 blocker | ||||
| Yes | 54 (22.88) | 7 (24.14) | 0.93 (0.38, 2.30) | .88 |
| No (REF) | 182 (77.12) | 22 (75.86) | ||
| Antidiabetic | ||||
| Yes | 46 (19.49) | 3 (10.34) | 2.10 (0.61, 7.23) | 0.24 |
| No (REF) | 190 (80.51) | 26 (89.66) | ||
| Coronary artery disease | ||||
| Yes | 41 (17.45) | 4 (13.79) | 1.32 (0.44, 4.00) | .62 |
| No (REF) | 194 (82.55) | 25 (86.21) | ||
| PAD | ||||
| Yes | 20 (8.51) | 3 (10.34) | 0.81 (0.22, 2.90) | .74 |
| No (REF) | 215 (91.49) | 26 (89.66) | ||
| Thromboembolic disease | ||||
| Yes | 6 (2.58) | 0 (0.00) | - | .99b |
| No (REF) | 227 (97.42) | 29 (100.00) | ||
| CVD | ||||
| Yes | 18 (7.69) | 2 (6.90) | 1.12 (0.25, 5.12) | .88 |
| No (REF) | 216 (92.31) | 27 (93.10) | ||
| Hypertension | ||||
| Yes | 135 (57.45) | 17 (58.62) | 0.95 (0.44, 2.08) | .90 |
| No (REF) | 100 (42.55) | 12 (41.38) | ||
| n | Mean (SD) | N | Mean (SD) | |||
|---|---|---|---|---|---|---|
| BMI | 233 | 27.49 (6.45) | 29 | 28.67 (6.12) | 0.97 (0.92, 1.03) | .35 |
| Systolic blood pressure (mmHg) | 234 | 128.92 (18.23) | 29 | 131.62 (14.75) | 0.99 (0.97, 1.01) | .44 |
BMI, body mass index; IUD, intrauterine device; HLD, hyperlipidemia; HTN, hypertension; NSAIDs, non steroidal anti-inflammatory drugs; PPI, proton pump inhibitor; SD, standard deviation; SSRI, selective serotonin reuptake inhibitor.
a
Significant at α < 0.05.
b
Fisher's exact test P value.