Table 2.
Incidence of Hepatocellular Carcinoma (%) After Liver Biopsy in Patients With Biopsy-proven Nonalcoholic Fatty Liver Disease (n = 1389)
| Marker | Category | Number of patients (%) | 1 y | 3 y | 5 y | 10 y | 15 y |
|---|---|---|---|---|---|---|---|
| aMAP score | 0–50 | 620 (45.3) | 0 | 0 | 0 | 0 | 0 |
| 50–60 | 545 (39.8) | 0 | 0.7 | 1.6 | 5.7 | 8.8 | |
| 60–100 | 203 (14.8) | 0.5 | 3.5 | 9.5 | 21.9 | 24.7 | |
| FIB-4 index | <1.30 | 589 (42.4) | 0 | 0 | 0 | 0 | 0.6 |
| 1.30–2.67 | 469 (33.8) | 0 | 0.5 | 0.8 | 1.6 | 5.1 | |
| >2.67 | 330 (23.8) | 0.3 | 2.6 | 7.5 | 21.8 | 23.4 | |
| ALBI score | ≤ −2.60 | 1126 (83.2) | 0 | 0.7 | 1.1 | 3.3 | 4.2 |
| > −2.60 | 228 (16.8) | 0.5 | 1.7 | 7.6 | 15.2 | 24.7 | |
| Histological fibrosis | F0–1 | 776 (55.9) | 0.1 | 0.1 | 1.2 | 1.8 | 2.3 |
| F2 | 394 (28.4) | 0 | 1.0 | 1.5 | 5.7 | 8.5 | |
| F3 | 195 (14.0) | 0 | 2.5 | 5.5 | 17.3 | 25.8 | |
| F4 | 24 (1.7) | 0 | 5.6 | 5.6 | 24.4 | 24.4 | |
| NAS score | 1–2 | 280 (20.2) | 0 | 0 | 0.6 | 0.6 | 3.4 |
| 3–4 | 747 (53.8) | 0.1 | 1.0 | 2.2 | 6.1 | 6.6 | |
| 5–8 | 362 (26.1) | 0 | 1.2 | 2.5 | 5.9 | 9.5 |