Meta-analyses evaluating the effects of IVUS guidance in the treatment of LMCA disease. Risk reduction (95% CI) for the meta-analyses that reported on the comparisons of IVUS- versus angiography-guided PCI in patients with left main coronary artery lesions for (A) all-cause mortality, (B) cardiovascular mortality, (C) myocardial infarction, (D) stent thrombosis, (E) TVR, and (F) TLR. All meta-analyses included randomized controlled trials and observational studies. IVUS, intravascular ultrasound; LMCA, left main coronary artery; PCI, percutaneous coronary intervention; TLR, target lesion revascularization; TVR, target vessel revascularization.