IVUS-CTO randomized controlled trial. Clinical impact of IVUS-guided CTO intervention. (A) Occurrence of MACE. (B) Composite of CD or MI. CD, cardiac death; CTO, chronic total occlusion; IVUS, intravascular ultrasound; MACE, major adverse cardiac event; MI, myocardial infarction. Reprinted with permission from Kim BK, Shin DH, Hong MK, et al. Clinical impact of intravascular ultrasound-guided chronic total occlusion intervention with zotarolimus-eluting versus Biolimus-eluting stent implantation: randomized study. Circ Cardiovasc Interv. 2015;8(7):e002592.