TABLE 2.

CCR5 polymorphisms on HIV-1 vertical transmission among the AZT-untreated group^a

Polymorphism	Group	Wt/Wt	Wt/Mut	Mut/Mut	Allele (%)	P valuee
CCR5-Δ32b	Uninfected	520	34	0	3.1	0.85
	HIV-1 infected	108	5	0	2.2	0.96
	Transmission rate	17.2%	12.8%	N/A		0.48
CCR2-64Ic	Uninfected	406	125	15	14.2	0.37
	HIV-1 infected	81	30	2	15.0	0.92
	Transmission rate	16.6%	19.4%	11.8%		0.61
CCR5-59353-T/Cd	Uninfected	174	250	105	43.5	0.68
	HIV-1 infected	37	43	26	44.8	0.18
	Transmission rate	17.5%	14.7%	19.8%		0.39
CCR5-59356-C/T	Uninfected	403	85	12	10.9	0.02
	HIV-1 infected	70	21	10	20.3	0.002
	Transmission rate	14.8%	19.8%	45.5%		<0.001
CCR5-59402-A/G	Uninfected	328	167	50	24.5	0.001
	HIV-1 infected	74	32	4	18.2	0.97
	Transmission rate	18.4%	16.1%	7.4%		0.12

^aOnly infants first seen at birth are considered. Wt, wild type; Mut, mutant; NA, not applicable. 

^bFor the NY-WNE cohort, the results are based on unpublished data of Pollack et al. 

^cIn the AZT-treated group, there was a trend toward reduced transmission among CCR2-64I heterozygotes (4.1% of 121) relative to wild-type homozygotes (10.0% of 338; P = 0.06). 

^dIn the AZT-treated group, there is a significantly lower rate of transmission among CCR5-59353-C/T heterozygotes (5.4%; P = 0.004) and CCR5-59353-C mutant homozygotes (6.1%; P = 0.04) compared to CCR5-59353-T wild-type homozygotes (14.0%). 

^eP values corresponding to uninfected and HIV-1-infected infants denote the Hardy-Weinberg equilibrium values, whereas those for transmission rates denote the significance of the difference in genotype distribution between the HIV-1-infected and uninfected groups (Pearson 2 × 3 chi-square values). The low Hardy-Weinberg value for CCR5-59402-A/G is due to different patterns of genotype distribution in the various racial groups; the genotype distribution of CCR5-59402-A/G is in Hardy-Weinberg equilibrium (P > 0.1) for each of the racial groups separately.