Table 3.
Interventions at Diagnosis in Type 3 AIP and Biochemical Outcomes
| Lipase on follow-up N (% of row total) |
Persistently normal lipasea N (%) |
Early (< 90 d) lipase elevation N (%) |
Late (> 90 d) lipase elevation N (%) |
Persistent lipase elevation N (%) |
|---|---|---|---|---|
| Intervention (n) (% of all patients) | ||||
| ICI-℞ held + No steroids (n = 95, 42%) | 58 (41%) | 8 (33%) | 4 (18%) | 25 (60%) |
| ICI-℞ held + steroids given (n = 44, 19%) | 25 (18%) | 6 (25%) | 4 (18%) | 9 (21%) |
| ICI not held + No steroid (n = 60, 26%) | 36 (26%) | 9 (38%) | 12 (55%) | 3 (7%) |
| Steroid given for another irAEs (n = 30, 13%) | 22 (15%) | 1 (4%) | 2 (9%) | 5 (12%) |
| Total (n = 229, 100%) | 141 (62%) | 24 (10%) | 22 (10%) | 42 (18%) |
a
Persistent biochemical resolution occurred more often when ICI-℞ was held (58/95) vs no intervention (36/60, P = .89) or with steroid and held ICI-℞ (25/44, P = .64) steroid treatment for another irAEs (22/30, P = .22) and steroid treatment whatever the cause (47/74, P = .99).