Table 3.
Association Between Ulcerative Colitis (UC) Treatment and Change in Fecal Urgency (N = 400)
| No persistent urgency (NPU)a N = 175 |
Urgency to none (UN)a N = 86 |
None to urgency (NU)a N = 56 |
Persistent urgency (PU)a N = 83 |
Chi-square P value (UN vs NPU)< | Chi-square P value (NU vs NPU)< | Chi-square P value (PU vs NPU)< | |
|---|---|---|---|---|---|---|---|
| Treatment at enrollment, n (%) | 164/175 (93.7%) | 80/86 (93.0%) | 52/56 (92.9%) | 78/83 (94.0%) | .832 | .821 | .935 |
| Biologic/JAKi only, n (%) | 40/175 (22.9%) | 14/86 (16.3%) | 14/56 (25.0%) | 15/83 (18.1) | |||
| IST only, n (%) | 4/175 (2.3%) | 1/86 (1.2%) | 0/56 (0.0%) | 3/83 (3.6%) | |||
| 5-ASA only, n (%) | 66/175 (37.7%) | 29/86 (33.7%) | 17/56 (30.4%) | 22/83 (26.5%) | |||
| Corticosteroid only, n (%) | 2/175 (1.1%) | 6/86 (7.0%) | 2/56 (3.6%) | 2/83 (2.4%) | |||
| ≥ 2 treatments at enrollment, n (%) | 57/175 (32.6%) | 40/86 (46.5%) | 20/56 (35.7%) | 42/86 (50.6%) | .028 | .664 | .005 |
| Any change in treatment during follow-up, n (%) | 48/175 (27.4%) | 45/86 (52.3%) | 25/56 (44.6%) | 44/86 (53.0%) | < .001 | .016 | < .001 |
| Biologic/JAKi only, n (%) | 7/48 (14.6%) | 4/45 (8.9%) | 5/25 (20.0%) | 8/44 (18.2%) | |||
| IST only, n (%) | 1/48 (2.1%) | 3/45 (6.7%) | 0/56 (0.0%) | 2/83 (4.5%) | |||
| 5-ASA only, n (%) | 12/48 (25.0%) | 8/45 (17.8%) | 5/25 (20.0%) | 4/44 (9.1%) | |||
| Corticosteroid only, n (%), | 11/48 (22.9%) | 10/45 (22.2%) | 1/251 (44.0%) | 6/44 (13.6%) | |||
| ≥ 2 changes in treatment, n (%) | 25/48 (52.1%) | 26/45 (57.8%) | 10/25 (40.0%) | 30/44 (68.2%) | .581 | .327 | .116 |
| Biologic treatment at enrollment and any change in treatment, n (%) | 20/175 (11.4%) | 21/86 (24.4%) | 13/56 (23.2%) | 29/83 (34.9%) | .007 | .028 | < .001 |
JAKi, Janus kinase inhibitors; TNFI, tumor necrosis factor inhibitors; 5-ASAs, 5-aminosalicylic acids; ISTs, immunosuppressant therapies.
a
NPU, no persistent urgency at enrollment or follow-up; UN, reported resolution of urgency after enrollment to follow-up; NU, reported onset of urgency after enrollment to follow-up; PU, reported urgency at both enrollment and follow-up.