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Volcano plot showing results from plasma metabolome-wide Mendelian randomization in the discovery stage. The metabolome-wide Mendelian randomization was performed based on summary statistics of genetic associations of a large-scale plasma metabolomics study and CRC meta-GWAS summary data to test associations of 651 plasma metabolites with CRC risk. Metabolites that survived after Bonferroni correction are labeled. CRC = colorectal cancer.
