TABLE 2.
Effect of treatment on HTLV-1 DNA sequencea
| Position and base (23) | Substitution | Amino acid change |
|---|---|---|
| 2699G | A | — |
| 2723A | G | — |
| 2972A | G | — |
| 3068T | A | — |
| 3098A | G | — |
| 3116G | A | — |
| 3227G | A | — |
| 3857C | T | — |
| 3911T | C | — |
| 3983A | T | Gln-His |
| 4148G | A | — |
| 4589T | C | — |
a
Sequencing revealed the emergence of a new dominant HTLV-1 DNA sequence with 11 nucleotide substitutions in the consensus sequence of the HTLV-1 pol gene from patient TAN. Each of these substitutions was first identified at the final time point, after 36 weeks of treatment with lamivudine, with the reexpansion of the amount of viral DNA. Before treatment, the nucleotide present at each of these positions was the same as that in the reference sequence (stub) (23). —, no amino acid change.