. 2024 Jul 17;57(15):2027–2037. doi: 10.1021/acs.accounts.4c00137

Table 1. A List of Prebiotically Plausible Organic Cofactors (Divided to Nucleotide-Derived and Other), Their Possible Functions and Binding Properties in Extant Proteins^4,10^a.

The percentage of the presumed “early” amino acids average involvement in binding to the cofactors is listed (the average overall content of “early” amino acids across PDB is 67%). For comparison with the presumed later coenzymes, refer to ref (4).

Table 1. A List of Prebiotically Plausible Organic Cofactors (Divided to Nucleotide-Derived and Other), Their Possible Functions and Binding Properties in Extant Proteins4,10a.

Table 1. A List of Prebiotically Plausible Organic Cofactors (Divided to Nucleotide-Derived and Other), Their Possible Functions and Binding Properties in Extant Proteins^4,10^a.