Fig. 7.

Intratracheal administration of thMSC-EVs attenuated inflammatory cytokine secretion in E. coli-induced ALI mice. The levels of pro-inflammatory cytokines such as CCL-2, IL-1α, IL-1β, INF-γ, TNF-α, and IL-6 were measured using ELISA. n = 18, 25, and 25 in the NC, ECS, and EME groups, respectively. Data are presented as a box and whisker plot. Whiskers represent the min and max. **, p < 0.01 vs. NC; *, p < 0.05 vs. NC; #, p < 0.05 vs. ECS. One-way ANOVA post hoc Tukey analysis was used. NC, normal control; ECS, E. coli-induced ALI control group; EME, thMSC-EVs treatment group after E. coli-induced ALI