Figure 2.

Exposome-wide association study using standard single-exposure regression models and machine learning pattern recognition based approach both identified etridiazole as negatively associated with worse semen parameters including lower total motile sperm, percent motility, and concentration. (A) Volcano plot of exposome-wide association study results, with the dashed line representing Bonferroni-corrected p-value cutoff threshold. (B) Boxplot of semen parameters among those with detectable levels of etridiazole compared to those with nondetectable levels of Etridiazole. (C) Heat plot of results PC regression. Green indicates negative association and the asterisk denotes statistical significance after Bonferroni correction. (D) Bar graph of posterior inclusion probability calculated from BKMR. (E) Estimated dose-response plots and associated 95% credible intervals from BKMR. Green line and credible interval indicates that the credible interval deviates from the null.