Table 2.

DISCOVER INOCA registry exclusion criteria.

Potential subjects will be excluded if any of the following conditions apply:

General Exclusion Criteria 1.Pregnant or nursing patients 2.Any myocardial infarction at index presentation or within 90 d prior to enrollment, defined as any electrocardiogram diagnostic for myocardial infarction OR elevation in serum troponin greater than the upper limit of the site-defined reference range 3.Known LVEF <50% or cardiogenic shock requiring pressors or mechanical circulatory assistance (eg, intra-aortic balloon pump, left ventricular assist device, other temporary cardiac support blood pump) 4.Renal insufficiency, defined as estimated glomerular filtration rate (eGFR) <30 mL/min/1.73 m2 (by the Modification of Diet in Renal Disease equation) or dialysis at the time of screening 5.Prior percutaneous coronary intervention 6.Planned percutaneous coronary intervention (PCI) 7.Prior coronary artery bypass graft surgery 8.Prior ST-elevation myocardial infarction 9.History of hypertrophic cardiomyopathy 10.History of infiltrative heart disease (eg, cardiac amyloidosis) 11.New York Heart Association Class IV congestive heart failure 12.Severe mitral regurgitation 13.Severe aortic stenosis 14.Severe pulmonary hypertension (mean pulmonary artery pressure ≥35 mm Hg or echocardiographic right ventricular systolic pressure ≥60 mm Hg) 15.Known history of unrepaired or repaired congenital heart disease 16.Past or pending heart transplant, or on the waiting list for organ transplant 17.Known other medical illness or known history of substance abuse that may cause noncompliance with the protocol, or is associated with a life expectancy of less than 1 year 18.Current or planned participation in a study of an investigational therapy

Angiographic Exclusion Criteria 1.Angiographic stenosis in any major epicardial vessel ≥70% by visual estimate 2.Angiographic stenosis in any major epicardial vessel ≥50% and <70% by visual estimate with FFR ≤0.80 or RFR ≤0.89

eGFR, estimated glomerular filtration rate; FFR, fractional flow reserve; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association; PCI, percutaneous coronary intervention; RFR, resting full cycle ratio.